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    hub sciencedirect scopus applications register login login go to scival suite username: password: remember me | not registered? Forgotten your username or password? Go to athens / institution login remote access activation home publications search my settings my alerts shopping cart help export citation purchase more options... Email article signed up for journal alerts [remove] alert me about new articles in this journal your selection(s) could not be saved due to an internal error. Please try again. Search     all fields     author advanced search     journal/book title     volume   issue   page search tips article outline is loading... Javascript required for article outline gastroenterology volume 118, issue 1, january 2000, pages 14–21 alimentary tract decreased interstitial cell of cajal volume in patients with slow-transit constipation ☆ ☆☆ chong–liang he * , † , larry burgart § , linan wang § , john pemberton ∥ , tonia young–fadok ∥ , joseph szurszewski * , † , gianrico farrugia * , † * department of physiology and biophysics † division of gastroenterology and hepatology § department of pathology ∥ department of surgery, mayo clinic, rochester, minnesota received 1 april 1999 accepted 14 september 1999 available online 27 october 2005 how to cite or link using doi permissions & reprints view full text purchase $31. 50 materials and methods results discussion acknowledgements references abstract background & aims: the cause of slow-transit constipation is incompletely understood. Recent observations suggest a central role for interstitial cells of cajal in the control of intestinal motility. The aim of this study was to determine the volume of interstitial cells of cajal in the normal sigmoid colon and in the sigmoid colon from patients with slow transit constipation. Methods: sigmoid colonic samples were stained with antibodies to protein gene product 9. 5, c-kit, and î±–smooth muscle actin. Three-dimensional reconstruction of regions of interest was performed using consecutive images collected on a laser scanning confocal microscope and analyze software. Results: volume of interstitial cells of cajal was significantly decreased in all layers of sigmoid colonic specimens from patients with slow-transit constipation compared with normal controls. buy viagra without prescription Neuronal structures within the colonic circular smooth muscle layer were also decreased. Conclusions: a decrease in the volume of interstitial cells of cajal may play an important role in the pathophysiology of slow-transit constipation. Gastroenterolgy 2000;118:14-21 abbreviations cy , indocarbocyanine; icc , interstitial cells of cajal; lrsc , lissamine rhodamine; pgp , protein gene product; sma , smooth muscle actin figures and tables from this article: fig. 1.  overview of the distribution of icc of cajal (a) in normal human sigmoid colon and (b) in the sigmoid colon of a patient with slow-transit constipation. Each panel is made up of a montage of several fields of view. C-kit–immunoreactive structures are shown in white. A decrease in c-kit–positive immunoreactivity in all regions of the sigmoid colon is evident in b compared with a. Sections were cut parallel to the longitudinal muscle layer for both panels. Lm, longitudinal muscle; my, myenteric plexus region; cm, circular muscle; sub, submucosal border. Bars = centred î¼m. Figure options view in workspace fig. 2.  distribution of icc and neuronal structures in the normal human sigmoid colon. (a) longitudinal muscle layer; (b) myenteric plexus region; (c) circular smooth muscle layer; (d) submucosal border (yellow double arrow). C-kit–positive immunoreactivity is shown in red and pgp 9. 5–positive immunoreactivity in gray. Bar = 50 î¼m. Figure options view in workspace fig. 3.  scatter plots showing the percent volume occupied by icc in the different regions of the sigmoid colon for each subject (stc, slow-transit constipation). Each point represents the mean ± sem of 4 areas analyzed for each region. buy cheap generic viagra online P < 0. 05 (controls vs. Stc) for all 4 regions. buy cheap generic viagra online Figure options view in workspace fig. 4.  distribution of icc and neuronal structures in human sigmoid colon from a patient with slow-transit constipation. overnight shipping viagra (a) longitudinal muscle layer; (b) myenteric plexus region; (c) circular smooth muscle layer; (d) submucosal border (yellow double arrow). C-kit–positive immunoreactivity is shown in red and pgp 9. 5–positive immunoreactivity in gray. Note the decreased number of immunoreactive structures for both c-kit (icc) and pgp 9. 5 (neuronal structures). Bar = 50 î¼m. buy cheap generic viagra online Figure options view in workspace fig. 5. buy cheap generic viagra online  high-magnification view of icc in the circular muscle layer. cheap viagra sales (a) single slice obtained from normal human sigmoid colon; (b) reconstruction of 20 consecutive slices at 0. 5-î¼m depth increments (z-axis). Note the fine processes of the individual icc (arrow). (c and d) similar data from human sigmoid colon of a patient with slow-transit constipation. Note the irregular surface markings and the loss of fine processes (arrow). Bar = 10 î¼m. Figure options view in workspace table 1. Patient demographics gc, geometric center. viagra tablets Table options view in workspace table 2. Control demographics table options view in workspace ☆ address request for reprint to: gianrico farrugia, m. D. , mayo clinic, guggen. cheap online viagra Ibrahim Tommy Executive Director

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